Zetia
ezetimibe (eh ZEH teh mib) 

What is the most important information I should know about Zetia?
 • Do not stop taking Zetia unless directed to do so by your doctor. It may be weeks or months before beneficial effects are seen from this medication.

What is Zetia?
 • Zetia reduces the amount of cholesterol absorbed by the body.
 • Zetia is used to reduce the amount of total cholesterol, LDL (bad) cholesterol, and apolipoprotein B (a protein needed to make cholesterol) in the blood. Zetia is used with a low cholesterol diet and, in some cases, other cholesterol lowering medications.
 • Zetia may also be used for purposes other than those listed in this medication guide.

What should I discuss with my healthcare provider before taking Zetia?
 • Before taking Zetia tell your doctor if you
      · have liver disease;
      · are taking another cholesterol-lowering medication; or
      · have unexplained muscle pain, tenderness, or weakness.
 • You may not be able to take Zetia, or you may require a dosage adjustment or special monitoring during treatment.
 • Zetia is in the FDA pregnancy category C. This means that it is not known whether Zetia will be harmful to an unborn baby. Do not take Zetiawithout first talking to your doctor if you are pregnant or could become pregnant during treatment.
 • It is not known whether Zetia passes into breast milk. Do not take Zetia without first talking to your doctor if you are breast-feeding a baby.

How should I take Zetia?
 • Take Zetia exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.
 • Take each dose with a full glass of water.
 • Take Zetia once a day with or without food. It may be easier to remember to take the medication if you take it at the same time every day.
 • Zetia should be taken 2 hours before or 4 hours after a bile acid sequestrant such as cholestyramine (Locholest, Prevalite, Questran), colestipol (Colestid), or colesevelam (Welchol).
 • Eat a low-fat, low-cholesterol diet. To see beneficial effects from Zetia avoid fatty, high-cholesterol foods.
 • Your doctor may want to monitor cholesterol levels, liver function, or other factors with blood tests before starting and during treatment with Zetia. Depending on the results of these tests, your doctor can determine how much monitoring you will require.
 • Do not stop taking Zetia unless directed to do so by your doctor. It may be weeks or months before beneficial effects are seen from this medication.
 • Store Zetia at room temperature away from moisture and heat.

What happens if I miss a dose of Zetia?
 • Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of the medication.

What happens if I overdose with Zetia?
 • Seek emergency medical attention.
 • Symptoms of an Zetia overdose are not known.

What should I avoid while taking Zetia?
 • Eat a low-fat, low-cholesterol diet. To see beneficial effects from Zetia avoid fatty, high-cholesterol foods.

What other drugs will affect Zetia?
 • Before taking Zetia, tell your doctor if you are taking:
      · another medicine to lower cholesterol such as gemfibrozil (Lopid), fenofibrate (Tricor), clofibrate (Atromid-S), atorvastatin (Lipitor), fluvastatin (Lescol), lovastatin (Altocor, Mevacor), pravastatin (Pravachol), or simvastatin (Zocor).
      · cyclosporine (Sandimmune, Neoral, Gengraf).
 • You may not be able to take Zetia, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medications listed above.
 • Zetia should be taken 2 hours before or 4 hours after a bile acid sequestrant such as cholestyramine (Locholest, Prevalite, Questran), colestipol (Colestid), or colesevelam (Welchol).
 • Drugs other than those listed here may also interact with cholestyramine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.

If you experience an uncommon allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives), stop taking Zetia and seek emergency medical attention.

Other, less serious side effects have also been reported, although uncommon. Continue to take Zetia and talk to your doctor if you experience
      · abdominal pain;
      · diarrhea; or
      · tiredness.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

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Your pharmacist may have more information about Zetia written for health professionals that you may read.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Click here for more information on Zetia from the manufacturer.

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